T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …

Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Immunotherapy with immune-checkpoint inhibitors (ICIs) and targeted therapy with BRAF
and MEK inhibitors have revolutionized the treatment of melanoma over the past decade …

Triple-negative breast cancer (TNBC) poses a significant challenge in terms of prognosis
and disease recurrence. The limited treatment options and the development of resistance to …

The CRISPR/Cas9 system is a powerful genome editing tool that has made enormous
impacts on next-generation molecular diagnostics and therapeutics, especially for genetic …

Simple Summary Lung cancer is the leading cause of cancer related mortality and morbidity
in the United States and worldwide. The advent of Immunotherapy has significantly …

A diverse range of viruses have well-established roles as the primary driver of oncogenesis
in various haematological malignancies and solid tumours. Indeed, estimates suggest that …

The use of a patient's own immune or tumor cells, manipulated ex vivo, enables Ag-or
patient-specific immunotherapy. Despite some clinical successes, there remain significant …