Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art
approach for unravelling the heterogeneity and complexity of RNA transcripts within …

Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

Regulation of cytokine production in stimulated T cells can be disrupted in autoimmunity,
immunodeficiencies, and cancer. Systematic discovery of stimulation-dependent cytokine …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

Deciphering the cell-state transitions underlying immune adaptation across time is
fundamental for advancing biology. Empirical in vivo genomic technologies that capture …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Cancer cells can evade natural killer (NK) cell activity, thereby limiting anti-tumor immunity.
To reveal genetic determinants of susceptibility to NK cell activity, we examined interacting …

Targeted transcriptional activation or interference can be induced with the CRISPR-Cas9
system (CRISPRa/CRISPRi) using nuclease-deactivated Cas9 fused to transcriptional …

Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …