Uveal melanoma (UM) is the most common primary intraocular malignancy among adults.
Despite significant advances in diagnosis and treatment, the general mortality of UM …

The emergence of antibody-drug conjugates (ADCs) as a potential therapeutic avenue in
cancer treatment has garnered significant attention. By combining the selective specificity of …

HIV-infected cells persist for decades in patients administered with antiretroviral therapy
(ART). Meanwhile, an alarming surge in drug-resistant HIV viruses has been occurring …

Affibodies and designed ankyrin repeat proteins (DARPins) are synthetic proteins originally
derived from the Staphylococcus aureus virulence factor protein A and the human ankyrin …

Simple Summary In this manuscript, we review the most relevant biological findings on
glioblastoma peritumoral tissue. This area, which is beyond frank tumoral tissue, presents a …

Urothelial carcinoma is the second most frequent genitourinary malignancy. Despite the
poor prognosis, new treatment options have emerged and have expanded the therapeutic …

Recent scientific data recognize the B7-H3 checkpoint molecule as a potential target for
immunotherapy of pediatric solid tumors (PSTs). B7-H3 is highly expressed in extracranial …

Abstract Antibody‐drug conjugates (ADCs), chemotherapeutic agents conjugated to an
antibody to enhance their targeted delivery to tumors, represent a significant advancement …

Abstract Probody therapeutics (Pb-Txs) are conditionally activated antibody–drug
conjugates (ADCs) designed to remain inactive until proteolytically activated in the tumor …

Adjusting the molecular size, the valency and the pharmacokinetics of drug conjugates are
as many leverages to improve their therapeutic window, notably by affecting tumor …