Precision medicine in rheumatic diseases: unlocking the potential of antibody-drug conjugates

Z Huang, Z Braunstein, J Chen, Y Wei, X Rao… - Pharmacological …, 2024 - ASPET
In the era of precision medicine, antibody-drug conjugates (ADCs) have emerged as a
cutting-edge therapeutic strategy. These innovative compounds combine the precision of …

[HTML][HTML] A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy

F Riccardi, M Dal Bo, P Macor, G Toffoli - Frontiers in Pharmacology, 2023 - frontiersin.org
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer
compounds that are widely used in the treatment of hematologic malignancies and solid …

Recognizing CRISPR as the new age disease‐modifying drug: Strategies to bioengineer CRISPR/Cas for direct in vivo delivery

R Thevendran, S Maheswaran - Biotechnology journal, 2023 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats (CRISPR) have established itself
as a frontier technology in genetic engineering. Researchers have successfully used the …

Research trend of publications concerning antibody-drug conjugate in solid cancer: a bibliometric study

X Qi, Y Li, W Liu, Y Wang, Z Chen, L Lin - Frontiers in pharmacology, 2022 - frontiersin.org
Background: Antibody-drug conjugate (ADC) is a promising therapy for solid cancer that has
raised global concern. Although several papers have reviewed the current state of ADCs in …

Antibody Drug Conjugates in Bladder Cancer: Current Milestones and Future Perspectives

R Alameddine, P Mallea, F Shahab… - Current treatment options …, 2023 - Springer
Opinion Statement Over the last several years, the treatment landscape of urothelial
carcinoma has witnessed an unprecedented expansion of therapeutic options including …

Plant-derived type I ribosome inactivating protein-based targeted toxins: a review of the clinical experience

DJ Flavell, SU Flavell - Toxins, 2022 - mdpi.com
Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a
targeting domain coupled chemically or genetically to a proteinaceous toxin payload. The …

[引用][C] Recent investigations on anticancer properties of azo-dyes

AS Sevastre, AD Hodorog - Medico Oncology, 2021 - medicosciencepress.org
Azo-dyes are widely used in cosmetic, textile, fibre, leather, printing and painting industries.
Besides their colouring function, azo compounds have been reported to have antibacterial …

Conjugation site characterization of antibody–drug conjugates using electron-transfer/higher-energy collision dissociation (EThcD)

Y Song, J Gao, Q Meng, F Tang, Y Wang, Y Zeng… - Analytica Chimica …, 2023 - Elsevier
Antibody–drug conjugates (ADCs) are formed by binding of cytotoxic drugs to monoclonal
antibodies (mAbs) through chemical linkers. A comprehensive evaluation of the critical …

Therapeutic antibodies: an overview

G Houen - Therapeutic Antibodies: Methods and Protocols, 2022 - Springer
Polyclonal immunoglobulin (Ig) preparations have been used for several decades for
treatment of primary and secondary immunodeficiencies and for treatment of some infections …

[HTML][HTML] HPLC-DAD validated method for DM4 and its metabolite S-Me-DM4 quantification in biological matrix for clinical and pharmaceutical applications

G Lovato, L Ciriolo, M Perrucci, L Federici… - … of Pharmaceutical and …, 2023 - Elsevier
The present study focuses on the development and validation of an HPLC-DAD
methodology for the detection of a potent chemotherapeutic agent, Maytansinoid Ravtansine …