Oncological diseases for a long time have remained one of the most significant health
problems of modern society, which causes great losses in its labour and vital potential …

Objective: To (I) provide an update of approved antibody drug conjugates (ADCs) and those
registered with NMPA,(II) give an overview of HER2-targeting ADCs as a mono-or …

Antibody-drug conjugates (ADCs) deliver effective medications to tumor cells that express
specific antigens, maximizing efficacy and reducing adverse effects. Because ado …

Methods: We looked at 13 FDA-approved ADCs approved between May 17, 2000 and
August 31, 2023 using a combination of searches in the English language from clinicaltrials …

Antibody–drug conjugates (ADCs) are targeted therapeutics generated by conjugation of
cytotoxic small molecules to monoclonal antibodies (mAbs) via chemical linkers. Due to their …

This chapter focuses on the structure-function-dynamics of antibodies and their importance
in the pharmaceutical sector and summarizes how recent computational tools play a vital …

The concept of a “magic bullet” as first formulated by Paul Ehrlich can perhaps most readily
be applied to antibodies “armed” with toxic substances or radionuclides. Most of the toxins …

Background: Gou Qi Zi (Lycium barbarum) is a traditional herbal medicine with antioxidative
effects. Although Gou Qi Zi has been used to prevent premature aging and in the treatment …

Immunotherapy is a new approach applied in treatment of infections, autoimmune diseases,
or cancer by activating or suppressing the immune system. Pre-clinical and clinical …

Trastuzumab emtansine (T-DM1, brand name: Kadcyla®) is the first FDA-approved antibody-
drug conjugate (ADC) for metastatic human epidermal growth factor receptor 2 positive …