Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Recent studies found that unbalanced copper homeostasis affect tumor growth, causing
irreversible damage. Copper can induce multiple forms of cell death, including apoptosis …

Increased intracellular toxicity due to an imbalance in copper homeostasis caused by
copper ion accumulation could regulate the rate of cancer cell growth and proliferation. The …

Background Cuproptosis is a copper-dependent cell death mechanism that is associated
with tumor progression, prognosis, and immune response. However, the potential role of …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Inducing cancer cell death has always been a research hotspot in life sciences. With the
continuous deepening and diversification of related research, the potential value of metal …

Copper is an essential trace element in an organism, and changes in copper levels in vivo
often indicate a diseased state. Copper and immunity have been discussed since the last …

Metal complexes in cancer therapy have attracted much interest mainly because metals
exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and …

The significantly increased copper level in tumor tissues and serum indicates the close
association of copper ions with tumor development, making copper ions attractive targets in …

Copper is a necessary cofactor vital for maintaining biological functions, as well as
participating in the development of cancer. A plethora of studies have demonstrated that …