Targeting JAK-STAT signaling to control cytokine release syndrome in COVID-19

W Luo, YX Li, LJ Jiang, Q Chen, T Wang… - Trends in pharmacological …, 2020 - cell.com
Recent advances in the pathophysiologic understanding of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has indicated that patients with severe …

Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic

S Noreen, I Maqbool, A Madni - European journal of pharmacology, 2021 - Elsevier
The current outbreak of novel COVID-19 challenges the development of an efficient
treatment plan as soon as possible. Several promising treatment options stand out as …

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

R Boudewijns, HJ Thibaut, SJF Kaptein, R Li… - Nature …, 2020 - nature.com
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …

Impact of cardiovascular disease and risk factors on fatal outcomes in patients with COVID-19 according to age: a systematic review and meta-analysis

SA Bae, SR Kim, MN Kim, WJ Shim, SM Park - Heart, 2021 - heart.bmj.com
Objective Previous studies that evaluated cardiovascular risk factors considered age as a
potential confounder. We aimed to investigate the impact of cardiovascular disease (CVD) …

Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China

Z Zeng, H Yu, H Chen, W Qi, L Chen, G Chen, W Yan… - Critical Care, 2020 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is a newly emerging infectious
disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome …

Pathogenesis of respiratory viral and fungal coinfections

F Salazar, E Bignell, GD Brown, PC Cook… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Biomimetic human disease model of SARS‐CoV‐2‐induced lung injury and immune responses on organ chip system

M Zhang, P Wang, R Luo, Y Wang, Z Li… - Advanced …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a global pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The models that can accurately …

Vascular alterations among young adults with SARS-CoV-2

SM Ratchford, JL Stickford… - American Journal …, 2021 - journals.physiology.org
While SARS-CoV-2 primarily affects the lungs, the virus may be inflicting detriments to the
cardiovascular system, both directly through angiotensin-converting enzyme 2 receptor and …

Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes

D Zhang, R Guo, L Lei, H Liu, Y Wang… - Journal of Leucocyte …, 2021 - academic.oup.com
Excessive monocyte/macrophage activation with the development of a cytokine storm and
subsequent acute lung injury, leading to acute respiratory distress syndrome (ARDS), is a …

COVID-19 pandemic: epidemiology, etiology, conventional and non-conventional therapies

A Rauf, T Abu-Izneid, A Olatunde… - International journal of …, 2020 - mdpi.com
Coronavirus disease 2019 (COVID-19), which reported in an outbreak in 2019 in Wuhan,
Hubei province, China, is caused by the SARS-CoV-2 virus. The virus belongs to the beta …