Abstract Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate
prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells and …

The epidemiological situation of SARS‐CoV‐2 in humans and animals is continually
evolving. To date, animal species known to transmit SARS‐CoV‐2 are American mink …

The SARS‐CoV‐2 virus and COVID‐19 pandemic continue to demand effective diagnostic
and therapeutic solutions. Finding these solutions requires highly functional molecular …

Background Remdesivir is an antiviral used to treat coronavirus disease 2019 (COVID-19),
which improves some clinical outcomes. Dexamethasone has been shown to be effective in …

Background Oral drugs against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) have received emergency use authorization for the treatment of mild-to-moderate …

The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …

The highly transmissible variants of SARS-CoV-2, the causative pathogen of the COVID-19
pandemic, bring new waves of infection worldwide. Identification of effective therapeutic …

Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-
threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against …

Obeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of
remdesivir (RDV) and is presently in phase 3 trials for COVID-19 treatment. In this work, we …

Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of a
1′-cyano-4-aza-7, 9-dideazaadenosine C-nucleoside (GS-441524) that is FDA approved …