Oral anticancer therapy mostly faces the challenges of low aqueous solubility, poor and
irregular absorption from the gastrointestinal tract, food-influenced absorption, high first-pass …

On 30 January 2020, the World Health Organization (WHO) declared the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic a public health emergency of …

The SARS-CoV-2 virus needs multiple copies for its multiplication using an enzyme RNA-
dependent RNA polymerase (RdRp). Remdesivir inhibits viral RdRp, controls the …

We assessed factors that determine the tissue-specific bioactivation of ProTide prodrugs by
comparing the disposition and activation of remdesivir (RDV), its methylpropyl and isopropyl …

The coronavirus disease 2019 (COVID-19) pandemic led to a remarkably rapid
development of a range of effective prophylactic vaccines, including new technologies that …

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
recent years not only caused a global pandemic but resulted in enormous social, economic …

By December 2021, the COVID-19 caused approximately 6.1 million deaths around the
world. Several vaccines have been approved, but there is still a need for non-prophylactic …

Pyridobenzothiazolone derivatives are a promising class of broad-spectrum antivirals.
However, the mode of action of these compounds remains poorly understood. The HeE1 …

Protease inhibitors (PIs) remain an important component of antiretroviral therapy for the
treatment of HIV-1 infection due to their high genetic barrier to resistance development …

The COVID-19 pandemic has highlighted the urgent need for the development of broad-
spectrum antivirals to enhance preparedness against future spillover of zoonotic viruses with …