New-age vaccine adjuvants, their development, and future perspective

SK Verma, P Mahajan, NK Singh, A Gupta… - Frontiers in …, 2023 - frontiersin.org
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …

Nanoparticle-based adjuvants and delivery systems for modern vaccines

B Filipić, I Pantelić, I Nikolić, D Majhen… - Vaccines, 2023 - mdpi.com
Ever since the development of the first vaccine, vaccination has had the great impact on
global health, leading to the decrease in the burden of numerous infectious diseases …

A novel defined TLR3 agonist as an effective vaccine adjuvant

KH Ko, SB Cha, SH Lee, HS Bae, CS Ham… - Frontiers in …, 2023 - frontiersin.org
Synthetic double-stranded RNA analogs recognized by Toll-like receptor 3 (TLR3) are an
attractive adjuvant candidate for vaccines, especially against intracellular pathogens or …

Adjuvants for COVID-19 vaccines

J Castrodeza-Sanz, I Sanz-Muñoz, JM Eiros - Vaccines, 2023 - mdpi.com
In recent decades, the improvement of traditional vaccines has meant that we have moved
from inactivated whole virus vaccines, which provoke a moderate immune response but …

A review of inactivated COVID-19 vaccine development in China: focusing on safety and efficacy in special populations

L Hu, J Sun, Y Wang, D Tan, Z Cao, L Gao, Y Guan… - Vaccines, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been widespread globally, and …

[HTML][HTML] Exploration of the immuno-adjuvant effect and mechanism of Anemoside B4 through network pharmacology and experiment verification

L Shen, H Luo, L Fan, Z Su, S Yu, S Cao, X Wu - Phytomedicine, 2024 - Elsevier
Background Extensive investigation has been undertaken about the utilization of saponin
adjuvants in vaccines intended for veterinary and human applications. AB4 is the main …

Non-glycosylated G protein with CpG ODN provides robust protection against respiratory syncytial virus without inducing eosinophilia

E Kawahara, T Shibata, T Hirai, Y Yoshioka - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Respiratory syncytial virus (RSV) vaccines targeting the fusion glycoprotein (F
protein) are highly effective clinically in preventing RSV challenges. The attachment …

Shaping neonatal immunization by tuning the delivery of synergistic adjuvants via nanocarriers

S Barman, F Borriello, B Brook, C Pietrasanta… - ACS chemical …, 2022 - ACS Publications
Adjuvanted nanocarrier-based vaccines hold substantial potential for applications in novel
early-life immunization strategies. Here, via mouse and human age-specific in vitro …

Evaluating immunogenicity of pathogen-derived T-cell epitopes to design a peptide-based smallpox vaccine

HQ Quach, IG Ovsyannikova, GA Poland… - Scientific reports, 2022 - nature.com
Despite the eradication in 1980, developing safe and effective smallpox vaccines remains
an active area of research due to the recent outbreaks and the public health concern that …

Fourth dose of microneedle array patch of SARS-CoV-2 S1 protein subunit vaccine elicits robust long-lasting humoral responses in mice

E Kim, J Shin, A Ferrari, S Huang, E An, D Han… - International …, 2024 - Elsevier
The COVID-19 pandemic has underscored the pressing need for safe and effective booster
vaccines, particularly in considering the emergence of new SARS-CoV-2 variants and …