Acute kidney injury (AKI) is a multifaceted syndrome that occurs in different settings. The
course of AKI can be variable, from single hit and complete recovery, to multiple hits …

The incidence of perioperative acute kidney injury (AKI) is more common than previously
recognized, especially in high-risk patients undergoing higher risk procedures. The growing …

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Background Cardiac surgery is associated with a high risk of postoperative acute kidney
injury (AKI) and subsequent loss of kidney function. We explored the clinical utility of urinary …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Cardioprotective strategies aim to salvage myocardium from ischemia/reperfusion injury and
to reduce infarct size and its consequences. Different stimuli, acting at sites remote from the …

The mortality from acute myocardial infarction (AMI) remains significant, and the prevalence
of post-myocardial infarction heart failure is increasing. Therefore, cardioprotection beyond …

Coronary artery disease (CAD) is one of the leading causes of death and disability in
Europe and worldwide. For patients with multi-vessel CAD, coronary artery bypass graft …

The translation of cardioprotection from robust experimental evidence to beneficial clinical
outcome for patients suffering acute myocardial infarction or undergoing cardiovascular …

Acute kidney injury (AKI) in the perioperative period is a common complication and is
associated with increased morbidity and mortality. A standard definition and staging system …