Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Human gut microbiota in health and disease: Unveiling the relationship

M Afzaal, F Saeed, YA Shah, M Hussain… - Frontiers in …, 2022 - frontiersin.org
The human gut possesses millions of microbes that define a complex microbial community.
The gut microbiota has been characterized as a vital organ forming its multidirectional …

Role of the gut microbiome in chronic diseases: a narrative review

A Vijay, AM Valdes - European journal of clinical nutrition, 2022 - nature.com
The gut microbiome, ie, the community of bacteria and other microorganisms living in the
human gut, has been implicated both directly and indirectly (mediating the effects of diet) on …

PPAR control of metabolism and cardiovascular functions

D Montaigne, L Butruille, B Staels - Nature Reviews Cardiology, 2021 - nature.com
Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023 - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

Gut microbiota and Covid-19-possible link and implications

D Dhar, A Mohanty - Virus research, 2020 - Elsevier
Covid-19 is a major pandemic facing the world today caused by SARS-CoV-2 which has
implications on our understanding of infectious diseases. Although, SARS-Cov-2 primarily …

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Standardized multi-omics of Earth's microbiomes reveals microbial and metabolite diversity

JP Shaffer, LF Nothias, LR Thompson, JG Sanders… - Nature …, 2022 - nature.com
Despite advances in sequencing, lack of standardization makes comparisons across studies
challenging and hampers insights into the structure and function of microbial communities …

Environmental endocrine-disrupting chemical exposure: role in non-communicable diseases

M Kumar, DK Sarma, S Shubham, M Kumawat… - Frontiers in public …, 2020 - frontiersin.org
The exponential growth of pollutant discharges into the environment due to increasing
industrial and agricultural activities is a rising threat for human health and a biggest concern …

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

Y Talmor-Barkan, N Bar, AA Shaul, N Shahaf… - Nature medicine, 2022 - nature.com
Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …