The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

V Carlini, DM Noonan, E Abdalalem, D Goletti… - Frontiers in …, 2023 - frontiersin.org
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …

Biochemistry of antioxidants: Mechanisms and pharmaceutical applications

S Losada-Barreiro, Z Sezgin-Bayindir, F Paiva-Martins… - Biomedicines, 2022 - mdpi.com
Natural antioxidants from fruits and vegetables, meats, eggs and fish protect cells from the
damage caused by free radicals. They are widely used to reduce food loss and waste …

[HTML][HTML] Natural tannins as anti-SARS-CoV-2 compounds

SC Wang, IW Chou, MC Hung - International Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Tannins are polyphenols enriched in wood, bark, roots, leaves, seeds and fruits of a variety
of plants. Over the last two decades, there has been an increasing interest in understanding …

The role of cyclodextrins in COVID-19 therapy—a literature review

B Almeida, C Domingues, F Mascarenhas-Melo… - International Journal of …, 2023 - mdpi.com
Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving
rise to a pandemic crisis. Therefore, it triggered tireless efforts to identify the mechanisms of …

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

VA Tirado-Kulieva, E Hernández-Martínez… - Heliyon, 2022 - cell.com
The COVID-19 pandemic caused by SARS-CoV-2 remains an international concern.
Although there are drugs to fight it, new natural alternatives such as polyphenols are …

Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation

M Mokrani, K Charradi, F Limam, E Aouani, MC Urdaci - Gut Pathogens, 2022 - Springer
Background Obesity is a worldwide health problem and a significant risk factor for diabetes
and cardiovascular diseases. Gut microbiota (GM) plays an essential role in obesity, and …

Polyphenols as potential inhibitors of SARS-CoV-2 RNA dependent RNA polymerase (RdRp)

Y Wu, D Crich, SD Pegan, L Lou, MC Hansen, C Booth… - Molecules, 2021 - mdpi.com
An increasing number of studies have demonstrated the antiviral nature of polyphenols, and
many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2. Our previous …

Molecular mechanisms of possible action of phenolic compounds in COVID-19 protection and prevention

N Gligorijevic, M Radomirovic, O Nedic… - International Journal of …, 2021 - mdpi.com
The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe
Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 …

Impact of zinc, glutathione, and polyphenols as antioxidants in the immune response against SARS-CoV-2

JM Perez de la Lastra, C Andres-Juan, FJ Plou… - Processes, 2021 - mdpi.com
SARS-CoV-2, the coronavirus triggering the disease COVID-19, has a catastrophic health
and socioeconomic impact at a global scale. Three key factors contribute to the …

Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients

MJ Coleman, KM Zimmerly, XO Yang - Biomolecules, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) causes infectious disease, and manifests in a wide range of symptoms from …