[HTML][HTML] Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

[HTML][HTML] Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?

SJ Kent, DS Khoury, A Reynaldi, JA Juno… - Nature Reviews …, 2022 - nature.com
The rapid development of multiple vaccines providing strong protection from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …

[PDF][PDF] The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

M Hoffmann, N Krüger, S Schulz, A Cossmann… - Cell, 2022 - cell.com
The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become
globally dominant. Further, the high number of mutations in the viral spike protein raised …

[PDF][PDF] A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2

Y Wang, M Yuan, H Lv, J Peng, IA Wilson, NC Wu - Immunity, 2022 - cell.com
Global research to combat the COVID-19 pandemic has led to the isolation and
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …

[HTML][HTML] A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts

J Chen, JA Neil, JP Tan, R Rudraraju, M Mohenska… - Nature Cell …, 2023 - nature.com
SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19
during pregnancy to negative birth outcomes and placentitis. However, the …

[PDF][PDF] Structures of Omicron spike complexes and implications for neutralizing antibody development

H Guo, Y Gao, T Li, T Li, Y Lu, L Zheng, Y Liu, T Yang… - Cell reports, 2022 - cell.com
The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries
worldwide. The high number of spike mutations is responsible for the broad immune evasion …

The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants

M Koutsakos, WS Lee, A Reynaldi, HX Tan, G Gare… - Immunity, 2022 - cell.com
Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in
breakthrough infections, likely reflecting residual vaccine-elicited immunity and recall of …

A broad and potent neutralization epitope in SARS-related coronaviruses

M Yuan, X Zhu, W He, P Zhou… - Proceedings of the …, 2022 - National Acad Sciences
Many neutralizing antibodies (nAbs) elicited to ancestral severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …

[HTML][HTML] Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

YC Hwang, RM Lu, SC Su, PY Chiang, SH Ko… - Journal of Biomedical …, 2022 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …