Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants

ER Haycroft, SK Davis, P Ramanathan, E Lopez… - Medical Microbiology …, 2023 - Springer
Abstract Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable
challenge to worldwide public health. The SARS-CoV-2 receptor-binding domain (RBD) is a …

Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants

NS Lima, M Mukhamedova, TS Johnston, DA Wagner… - bioRxiv, 2022 - biorxiv.org
While humoral immune responses to infection or vaccination with ancestral SARS-CoV-2
have been well-characterized, responses elicited by infection with variants are less …

Omicron variant: an acute public health problem

EA Adebowale, RO Adesola - … Journal of Travel Medicine and Global …, 2022 - ijtmgh.com
The coronavirus disease 2019 (COVID-19) has persisted as a pandemic for just over two
years; vaccines have been developed to prevent the clinical disease and treatment …

[HTML][HTML] A large-scale systematic survey of SARS-CoV-2 antibodies reveals recurring molecular features

Y Wang, M Yuan, J Peng, IA Wilson, NC Wu - bioRxiv, 2021 - ncbi.nlm.nih.gov
In the past two years, the global research in combating COVID-19 pandemic has led to
isolation and characterization of numerous human antibodies to the SARS-CoV-2 spike …

[HTML][HTML] Infection and vaccine induced Spike antibody responses against SARS-CoV-2 Variants of concern in immune naïve children and adults

A Pillay, A Yeola, F Tea, M Denkova, S Houston… - 2022 - europepmc.org
A more efficient and effective adaptive humoral immune response has been proposed as the
basis of the usually favourable outcome of paediatric COVID-19. The breadth of virus and …

Exploring the Interplay of Mutations, Viral Stability, and Implications for Innovative Vaccination Strategies and Therapeutic Approaches Among Various SARS-CoV-2 …

Z Abduljaleel - 2024 - researchsquare.com
This study explores the infectivity of SARS-CoV-2 and its implications for immune evasion,
resulting in significant variants carrying mutations that facilitate evasion from host cells. As …

[PDF][PDF] Synthetic selection and engineering of antibodies

RA Ehling - 2022 - research-collection.ethz.ch
Antibodies produced by B cells are diverse molecules that bind and neutralize foreign
antigens with high specificity and serve as a critical component of adaptive immunity …

[PDF][PDF] De novo prediction of antibody variable domains from antigen primary structure with deep learning approaches

P Gater, P Widera, M Pocock, Y Ng, S Gan, A Wipat - researchgate.net
The COVID-19 pandemic incited an unprecedented demand for novel drug therapeutics,
and in doing so, highlighted the shortcomings of therapeutic monoclonal antibody …