Brugada syndrome (BrS) is diagnosed by a coved-type ST-segment elevation in the right
precordial leads on the electrocardiogram (ECG), and it is associated with an increased risk …

The NaV1. 8 sodium channel, encoded by gene SCN10A, was initially termed sensory
neuron–specific (SNS) due to prominent expression in primary sensory neurons including …

Ion channels are critical for all aspects of cardiac function, including rhythmicity and
contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac …

Background—Purkinje cells (PCs) comprise the most distal component of the cardiac
conduction system, and their unique electrophysiological properties and the anatomic …

Background and Purpose N a V 1.8 ion channels have been highlighted as important
molecular targets for the design of low MW blockers for the treatment of chronic pain. Here …

The cardiac conduction system is a specialized tract of myocardial cells responsible for
maintaining normal cardiac rhythm. Given its critical role in coordinating cardiac …

Mammalian species express nine functional voltage-gated Na+ channels. Three of them, the
cardiac-specific isoform Nav1. 5 and the neuronal isoforms Nav1. 8 and Nav1. 9, are …

Background—Recent genome-wide association studies in which selected community
populations are used have identified genomic signals in SCN10A influencing PR duration …

Background: Genetic variants in SCN10A, encoding the neuronal voltage-gated sodium
channel NaV1. 8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac …

In cardiac myocytes, the voltage‐gated sodium channel NaV1. 5 opens in response to
membrane depolarisation and initiates the action potential. The NaV1. 5 channel is typically …