Pain remains a major clinical challenge, severely afflicting around 6% of the population at
any one time. Channelopathies that underlie monogenic human pain syndromes are of …

Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this
study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a …

The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction
time. The PR interval is heritable, provides important information about arrhythmia risk, and …

Background—Genome-wide association studies have shown that the common single
nucleotide polymorphism rs6800541 located in SCN10A, encoding the voltage-gated Nav1 …

Mutations of the cardiac sodium channel (Nav1. 5) can induce gain or loss of channel
function. Gain-of-function mutations can cause long QT syndrome type 3 and possibly atrial …

Pain is an increasing clinical challenge affecting about half the population, with a substantial
number of people suffering daily intense pain. Such suffering can be linked to the dramatic …

The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007
by the National Human Genome Research Institute (NHGRI) of the National Institutes of …

Slowly inactivating Na+ channels conducting “late” Na+ current (INa, late) contribute to
ventricular arrhythmogenesis under pathological conditions. INa, late was also reported to …

Sudden cardiac death (SCD) resulting from ventricular tachyarrhythmia is a major
contributor to mortality. Clinical management of SCD, currently based on clinical markers of …

Background—Considerable interest exists in the identification of genetic modifiers of
disease severity in the long-QT syndrome (LQTS) as their identification may contribute to …