The trend towards more minimally invasive procedures in the past few decades has resulted
in an exponential growth in fluoroscopy-guided catheter-based cardiology procedures. As …

The generation and propagation of the cardiac impulse is the central function of the cardiac
conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of …

Ischemic heart disease is a significant public health problem with high mortality and
morbidity. Extensive scientific investigations from basic sciences to clinics revealed …

Aims To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare
coding sequence variation in the SCN10A gene, which encodes the voltage-gated sodium …

Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side
effects and low efficacy. Thus, the identification of new antiarrhythmic targets is of clinical …

Heart failure is associated with atrioventricular (AV) node dysfunction, and AV node
dysfunction in the setting of heart failure is associated with an increased risk of mortality and …

Background—Long-QT syndrome (LQTS) is characterized by such striking clinical
heterogeneity that, even among family members carrying the same mutation, clinical …

Aims In heart failure (HF), enhanced persistent Na+ current (INaL) exerts detrimental effects
on cellular electrophysiology and can induce arrhythmias. However, the underlying …

We have shown that the gene SCN10A encoding the sodium channel Nav1. 8 is a
susceptibility factor for heart block and serious ventricular arrhythmia. Since Nav1. 8 is …

Background—The P wave on an ECG is a measure of atrial electric function, and its
characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave …