Background—The PR interval on the ECG reflects atrial depolarization and atrioventricular
nodal delay which can be partially differentiated by P wave duration and PR segment …

Aims Transgenic mice are frequently used to investigate the role of genes involved in
cardiac conduction. The QRS duration calculated from the electrocardiogram (ECG) is a …

Background: Nav1. 8 sodium channels, encoded by SCN10A, are preferentially expressed
in nociceptive neurons and play an important role in human pain. Although rare gain-of …

The voltage-gated cardiac sodium channel (Na v 1.5) is a mega-complex comprised of a
pore-forming α subunit and 4 ancillary β-subunits together with numerous protein partners …

Context Protein kinase C-β (PKC-β) is a cell-signaling intermediate implicated in
development of diabetic complications. Objective To examine the risk association of PKC-β …

In recent years genome-wide association studies (GWAS) have uncovered numerous
chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia …

Sudden cardiac death (SCD) is a prevalent cause of death in Western societies. Genome-
wide association studies (GWAS) conducted over the last few years have uncovered …

Aims In hypertrophy and heart failure, the proarrhythmic persistent Na+ current (INaL) is
enhanced. We aimed to investigate the electrophysiological role of neuronal sodium …

Potassium currents determine the resting membrane potential and govern repolarisation in
cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on …

Purpose Several studies have indicated a potential role for SCN10A/Na V 1.8 in modulating
cardiac electrophysiology and arrhythmia susceptibility. However, by which mechanism …