In the six decades that have followed the work of Hodgkin and Huxley, multiple generations
of neuroscientists and biophysicists have built upon their pivotal contributions. It is now clear …

Late sodium current has long been linked to dysrhythmia and contractile malfunction in the
heart. Despite the increasing body of accumulating information on the subject, our …

The rationale for genome-wide association study (GWAS) results is sequence variation in cis-
regulatory elements (CREs) modulating a target gene's expression as the major cause of …

Heart failure (HF) is a complex clinical syndrome resulting from structural or functional
impairments of ventricular filling or ejection of blood. HF has a poor prognosis and the …

The voltage-gated sodium channel Nav1. 8 is known to function in the transmission of pain
signals induced by cold, heat, and mechanical stimuli. Sequence variants of human Nav1. 8 …

First‐degree atrioventricular (AV) block is a delay within the AV conduction system and is
defined as a prolongation of the PR interval beyond the upper limit of what is considered …

Abstract Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are
common complex phenotypes, which are affected by multiple genetic and environmental …

Background Recent genome-wide association studies (GWAS) have identified novel loci
associated with sudden cardiac death (SCD). Despite this progress, identified DNA variants …

Background Mutations in the coding sequence of SCN 5A, which encodes the cardiac Na+
channel α subunit, have been associated with inherited susceptibility to various arrhythmias …

Aims Emerging evidences indicate that SCN10A/NaV1. 8 is associated with cardiac
conduction and atrial fibrillation, but the exact role of NaV1. 8 in cardiac electrophysiology …