Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

Most of our transcribed RNAs are represented by non-coding sequences. Long non-coding
RNAs (lncRNAs) are transcripts with no or very limited protein coding ability and a length> …

With advanced technologies to map RNA modifications, our understanding of them has
been revolutionized, and they are seen to be far more widespread and important than …

RNA modification is a dynamic and reversible process regulated by a series of writers,
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …

Abstract N 6-Methyladenosine (m6A) is one of the most abundant internal chemical
modifications on eukaryote mRNA and is involved in numerous essential molecular …

As one of the most prevalent post-transcriptional epigenetic modifications, N5-
methylcytosine (m5C) plays an essential role in various cellular processes and disease …

methylcytosine (m5C) modification, which is mainly induced by the RNA methyltransferase
NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional …

Recent advances in epitranscriptomics have unveiled functional associations between RNA
modifications (RMs) and multiple human diseases, but distinguishing the functional or …

An immunosuppressive state is a typical feature of the tumor microenvironment. Despite the
dramatic success of immune checkpoint inhibitor (ICI) therapy in preventing tumor cell …

The alphabet of building blocks for RNA molecules is much larger than the standard four
nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of …