Quality control and analytic best practices for testing genetic models of sex differences in large populations

EA Khramtsova, MA Wilson, J Martin, SJ Winham… - Cell, 2023 - cell.com
Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …

Sex-specific DNA methylation: impact on human health and development

P Govender, M Ghai, M Okpeku - Molecular Genetics and Genomics, 2022 - Springer
Human evolution has shaped gender differences between males and females. Over the
years, scientific studies have proposed that epigenetic modifications significantly influence …

[HTML][HTML] Canonical correlation analysis for multi-omics: Application to cross-cohort analysis

MZ Jiang, F Aguet, K Ardlie, J Chen, E Cornell… - PLoS …, 2023 - journals.plos.org
Integrative approaches that simultaneously model multi-omics data have gained increasing
popularity because they provide holistic system biology views of multiple or all components …

[HTML][HTML] Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions

B Doshi, SR Athans, A Woloszynska - Oncogenesis, 2023 - nature.com
Sex and gender disparities in bladder cancer have long been a subject of interest to the
cancer research community, wherein men have a 4 times higher incidence rate than women …

[HTML][HTML] Pre-and peri-natal hurricane exposure alters DNA methylation patterns in children

E Kello, AR Vieira, S Rivas-Tumanyan… - Scientific Reports, 2023 - nature.com
Hurricane Maria was the worst recorded natural disaster to affect Puerto Rico. Increased
stress in pregnant women during and in the aftermath of the hurricane may have induced …

Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study

A Reiner, KM Bakulski, JD Fisher, JF Dou… - Epigenetics, 2023 - Taylor & Francis
The prevalence and severity of many diseases differs by sex, potentially due to sex-specific
patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have …

InterpolatedXY: a two-step strategy to normalize DNA methylation microarray data avoiding sex bias

Y Wang, TJ Gorrie-Stone, OA Grant… - …, 2022 - academic.oup.com
Motivation Data normalization is an essential step to reduce technical variation within and
between arrays. Due to the different karyotypes and the effects of X chromosome …

[HTML][HTML] A Review of the Epigenetic Clock: Emerging Biomarkers for Asthma and Allergic Disease

D Vasileva, CMT Greenwood, D Daley - Genes, 2023 - mdpi.com
DNA methylation (DNAm) is a dynamic, age-dependent epigenetic modification that can be
used to study interactions between genetic and environmental factors. Environmental …

[HTML][HTML] Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas

LM Legault, M Breton-Larrivée… - Biology of sex …, 2024 - Springer
Background The placenta is vital for fetal development and its contributions to various
developmental issues, such as pregnancy complications, fetal growth restriction, and …

[HTML][HTML] Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia

M Tesfaye, LM Spindola, AK Stavrum, A Shadrin… - Molecular …, 2024 - nature.com
Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-
known; however, the molecular mechanisms underlying these differences remain unclear …