Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …

WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

Orthopedic implants containing biodegradable magnesium have been used for fracture
repair with considerable efficacy; however, the underlying mechanisms by which these …

The neuronal engagement of the peripheral nerve system plays a crucial role in regulating
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …

Delayed healing and nonunion of fractures represent enormous burdens to patients and
healthcare systems. There are currently no approved pharmacological agents for the …

Background Osteogenesis and angiogenesis are important for bone fracture healing. Irisin is
a muscle-derived monokine that is associated with bone formation. Methods To demonstrate …

Osteoporosis is a highly prevalent disorder characterized by the loss of bone mass and
microarchitecture deterioration of bone tissue, attributed to various factors, including …

Background: Romosozumab is a bone-forming antibody that increases bone formation and
decreases bone resorption. We conducted a double-blinded, randomized, phase-2, dose …

Distraction osteogenesis (DO) is a well-established surgical technique for treating bone
defect and limb lengthening. The major drawback of DO is the long treatment period as the …

Osteoporosis and its associated fracture risk has become one of the major health burdens in
our aging population. Currently, bisphosphonate, one of the most popular antiresorptive …