A study of miRNAs as cornerstone in lung cancer pathogenesis and therapeutic resistance: A focus on signaling pathways interplay

AS Doghish, A Ismail, MA Elrebehy… - … -Research and Practice, 2022 - Elsevier
Lung cancer (LC) is the most common cancer-related death globally, and many efforts have
been made to improve the patient care of LC patients, as well as the development of efficient …

Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies

AQ Khan, EI Ahmed, NR Elareer, K Junejo, M Steinhoff… - Cells, 2019 - mdpi.com
Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …

The roles of MicroRNA in lung cancer

KL Wu, YM Tsai, CT Lien, PL Kuo, JY Hung - International journal of …, 2019 - mdpi.com
Lung cancer is the most devastating malignancy in the world. Beyond genetic research,
epigenomic studies—especially investigations of microRNAs—have grown rapidly in …

LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway

C Fu, D Li, X Zhang, N Liu, G Chi, X Jin - Neurotherapeutics, 2018 - Springer
The current research was aimed at probing into the role of long noncoding RNA (lncRNA)
PVT1 in the pathogenesis of glioma and the regulatory mechanism of PVT1/miR-128 …

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

J Cai, L Fang, Y Huang, R Li, X Xu, Z Hu… - Nature …, 2017 - nature.com
Cancer chemoresistance and metastasis are tightly associated features. However, whether
they share common molecular mechanisms and thus can be targeted with one common …

New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

Y Wang, L Wang, C Chen, X Chu - Molecular cancer, 2018 - Springer
Angiogenesis is essential for tumor growth and metastasis. Understanding the regulation of
tumor angiogenesis has become increasingly important. MicroRNAs (miRNAs) are small …

Role of miRNAs in tumor and endothelial cell interactions during tumor progression

F Orso, L Quirico, D Dettori, R Coppo, F Virga… - Seminars in Cancer …, 2020 - Elsevier
Cancer is a multistep disease based on crucial interactions between tumor cells and the
microenvironment (extracellular matrix and stroma/immune cells). In fact, during …

Targeting strategies for the combination treatment of cancer using drug delivery systems

J Kydd, R Jadia, P Velpurisiva, A Gad, S Paliwal, P Rai - Pharmaceutics, 2017 - mdpi.com
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy
treatment—due to the hostile tumor microenvironment—that create a significant challenge …

MiR-182-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-C

S Yan, H Wang, X Chen, C Liang, W Shang, L Wang… - Cancer letters, 2020 - Elsevier
MicroRNAs (miRNAs) are gene modulators essential for biological processes. However, the
precise functions of miRNAs in growth and development of colon cancer are still elusive. To …

Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …