U Ishimoto-Namiki, Y Ino, M Esaki… - The American Journal …, 2023 - journals.lww.com
Acinar cell carcinoma (ACC) is a rare and highly malignant pancreatic tumor. Owing to histologic similarity, ACC is often difficult to distinguish from other solid medullary pancreatic …
Contrasting evidence is present regarding the contribution of stem/progenitor cell populations to pancreatic regeneration in diabetes. Interestingly, a cell compartment with …
Typical clustering methods for single-cell and spatial transcriptomics struggle to identify rare cell types, while approaches tailored to detect rare cell types gain this ability at the cost of …
In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the pancreatic cells for regeneration or replenishment is a critical need. Diverse lines of …
X Fang, Y Zhang, R Miao, Y Zhang, R Yin… - Biomedicine & …, 2024 - Elsevier
Single-cell sequencing is a novel and rapidly advancing high-throughput technique that can be used to investigating genomics, transcriptomics, and epigenetics at a single-cell level …
E Dirice, G Basile, S Kahraman, D Diegisser, J Hu… - JCI insight, 2022 - ncbi.nlm.nih.gov
Adaptation to increased insulin demand is mediated by β cell proliferation and neogenesis, among other mechanisms. Although it is known that pancreatic β cells can arise from ductal …
A Isaacson, FM Spagnoli - Current Opinion in Genetics & Development, 2021 - Elsevier
Diabetes is a group of metabolic disorders, which results from insufficient functional pancreatic β-cell mass either due to the autoimmune destruction of insulin producing β-cells …
X Yang, X Hou, J Zhang, Z Liu, G Wang - Genes & Immunity, 2023 - nature.com
Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal immune regulation, leading to damage to host organs. The complicated pathogenesis and …
T Liu, X Zou, R Ruze, Q Xu - Frontiers in Endocrinology, 2023 - frontiersin.org
Pancreatic β-cell function impairment and insulin resistance are central to the development of obesity-related type 2 diabetes mellitus (T2DM). Bariatric surgery (BS) is a practical …