The use of patient-derived organoids (PDOs) to characterize therapeutic sensitivity and
resistance is a promising precision medicine approach, and its potential to inform clinical …

Acinar cell carcinoma (ACC) is a rare and highly malignant pancreatic tumor. Owing to
histologic similarity, ACC is often difficult to distinguish from other solid medullary pancreatic …

Contrasting evidence is present regarding the contribution of stem/progenitor cell
populations to pancreatic regeneration in diabetes. Interestingly, a cell compartment with …

Typical clustering methods for single-cell and spatial transcriptomics struggle to identify rare
cell types, while approaches tailored to detect rare cell types gain this ability at the cost of …

In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the
pancreatic cells for regeneration or replenishment is a critical need. Diverse lines of …

Single-cell sequencing is a novel and rapidly advancing high-throughput technique that can
be used to investigating genomics, transcriptomics, and epigenetics at a single-cell level …

Adaptation to increased insulin demand is mediated by β cell proliferation and neogenesis,
among other mechanisms. Although it is known that pancreatic β cells can arise from ductal …

Diabetes is a group of metabolic disorders, which results from insufficient functional
pancreatic β-cell mass either due to the autoimmune destruction of insulin producing β-cells …

Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal
immune regulation, leading to damage to host organs. The complicated pathogenesis and …

Pancreatic β-cell function impairment and insulin resistance are central to the development
of obesity-related type 2 diabetes mellitus (T2DM). Bariatric surgery (BS) is a practical …