[HTML][HTML] An overview of DNA methylation-derived trait score methods and applications
Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …
thousands of individuals. These studies typically test the associations between individual …
[HTML][HTML] Genetic and epigenetic background of diabetic kidney disease
N Sandholm, EH Dahlström, PH Groop - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …
A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation
DNA methylation comprises a cumulative record of lifetime exposures superimposed on
genetically determined markers. Little is known about methylation dynamics in humans …
genetically determined markers. Little is known about methylation dynamics in humans …
Low-input and single-cell methods for Infinium DNA methylation BeadChips
Abstract The Infinium BeadChip is the most widely used DNA methylome assay technology
for population-scale epigenome profiling. However, the standard workflow requires over 200 …
for population-scale epigenome profiling. However, the standard workflow requires over 200 …
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes
Z Chen, E Satake, MG Pezzolesi, ZI Md Dom… - Science Translational …, 2024 - science.org
Variation in DNA methylation (DNAmet) in white blood cells and other cells/tissues has been
implicated in the etiology of progressive diabetic kidney disease (DKD). However, the …
implicated in the etiology of progressive diabetic kidney disease (DKD). However, the …
[HTML][HTML] Using epigenomics to understand cellular responses to environmental influences in diseases
It is a generally accepted model that environmental influences can exert their effects, at least
in part, by changing the molecular regulators of transcription that are described as …
in part, by changing the molecular regulators of transcription that are described as …
DNA methylation signature aberration as potential biomarkers in treatment-resistant schizophrenia: Constructing a methylation risk score using a machine learning …
AKM Lu, JJ Lin, HH Tseng, XY Wang, FL Jang… - Journal of Psychiatric …, 2023 - Elsevier
Abstract Treatment-resistant schizophrenia (TRS) is defined as a non-response to at least
two trials of antipsychotic medication with an adequate dose and duration. We aimed to …
two trials of antipsychotic medication with an adequate dose and duration. We aimed to …
Methylation profiles at birth linked to early childhood obesity
Childhood obesity represents a significant global health concern and identifying its risk
factors is crucial for developing intervention programs. Many “omics” factors associated with …
factors is crucial for developing intervention programs. Many “omics” factors associated with …
Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine
The integration of multiomics data with detailed phenotypic insights from electronic health
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
[HTML][HTML] Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans
The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been
inconsistent, with few studies investigating biological outcomes in humans. We profiled …
inconsistent, with few studies investigating biological outcomes in humans. We profiled …