Background The Natural History and Neuroprotection in Parkinson Plus Syndromes
(NNIPPS) study was a large phase III randomized placebo-controlled trial of riluzole in …

Multiple system atrophy is a rapidly progressive and fatal neurodegenerative disorder. While
numerous preclinical studies suggested efficacy of potentially disease modifying agents …

Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that
manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and …

Cognitive impairment is common in patients with the neurodegenerative tauopathy
progressive supranuclear palsy (PSP). Although a pattern of 'subcortical'cognitive …

With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors
(NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4 …

Background The trophic, anti-apoptotic and regenerative effects of bone marrow
mesenchymal stromal cells (MSC) may reduce neuronal cell loss in neurodegenerative …

Osaki Y, Morita Y, Kuwahara T, Miyano I, Doi Y. Prevalence of Parkinson's disease and
atypical parkinsonian syndromes in a rural Japanese district. Acta Neurol Scand: 2011: 124 …

Cognitive impairment is integral to the syndrome of progressive supranuclear palsy. It is
most commonly described as a frontal dysexecutive syndrome but other impairments include …

The knowledge obtained recently on atypical parkinsonian conditions points out the major
deficits in this field. With the expanding phenotypical spectrum of atypical parkinsonian …

Purpose Dopamine transporter (DAT) imaging can demonstrate presynaptic dopaminergic
neuronal loss in Parkinson's disease (PD). However, differentiating atypical parkinsonism …