Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …

Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …

Individuals with Down syndrome are genetically predisposed to developing acute
megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML …

Fetal and adult hematopoietic stem cells (HSCs) have distinct proliferation rates, lineage
biases, gene expression profiles, and gene dependencies. Although these differences are …

Given the plasticity of hematopoietic stem and progenitor cells, multiple routes of
differentiation must be blocked in the the pathogenesis of acute myeloid leukemia, the …

The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in
infants and early childhood and is associated with dismal outcome. Here, we demonstrate …

Super Enhancers (SEs) are clusters of regulatory elements associated with cell identity and
disease. However, whether these elements are induced by oncogenes and can regulate …

Pediatric acute myeloid leukemia expressing the ETO2:: GLIS2 fusion oncogene is
associated with dismal prognosis. Previous studies have shown that ETO2:: GLIS2 can …

Acute megakaryoblastic leukemia (AMKL) is a rare, developmentally restricted, and highly
lethal cancer of early childhood. The paucity and hypocellularity (due to myelofibrosis) of …