Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

NF-κB-mediated inflammatory phenotypic switching of vascular smooth muscle cells
(VSMCs) plays a central role in atherosclerosis and neointimal formation. However, little is …

Abstract Introduction Several microRNAs (miRNAs) have been implicated in Alzheimer's
disease pathogenesis, but the evidence from individual case-control studies remains …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is accompanied by
deficits in memory and cognitive functions. The disease is pathologically characterised by …

Aging affects most living organisms and includes the processes that reduce health and
survival. The chronological and the biological age of individuals can differ remarkably, and …

Protein aggregation is classically considered the main cause of neuronal death in
neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration …

Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

With Alzheimer's disease (AD) exhibiting reduced ability of neural stem cell renewal, we
hypothesized that de novo mutations controlling embryonic development, in the form of brain …

The identification of mechanisms associated with Alzheimer's disease (AD) development in
mild cognitive impairment (MCI) would be of great usefulness to clarify AD pathogenesis and …