A hallmark of Alzheimer's disease (AD) are the proteinaceous aggregates formed by the
amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid plaques. The …

In the rapidly evolving field of Alzheimer's Disease (AD) research, the intricate role of
Hydrogen Sulfide (H2S) has garnered critical attention for its diverse involvement in both …

Although the long-standing Amyloid Cascade Hypothesis (ACH) has been largely
discredited, its main attribute, the centrality of amyloid-beta (Aβ) in Alzheimer's disease (AD) …

For at least two reasons, the current transgenic animal models of Alzheimer's disease (AD)
appear to be patently inadequate. They may be useful in many respects, the AD models; …

Neurodegenerative diseases are a heterogeneous group of age-related disorders
characterised by the progressive degeneration or death of neurons in the central or …

The alarming rise of cognitive impairment and memory decline and limited effective
solutions present a worldwide concern for dementia patients. The multivariant role of the …

Abstract With the Amyloid Cascade Hypothesis (ACH) largely discredited, the ACH2. 0
theory of Alzheimer's disease (AD) has been recently introduced. AD is triggered by amyloid …

The centrality of amyloid-beta (Aβ) is an indisputable tenet of Alzheimer's disease (AD). It
was initially indicated by the detection (1991) of a mutation within Aβ protein precursor …

CLEC4G, a glycan-binding receptor, has previously been demonstrated to inhibit Aβ
generation, yet its brain localization and functions in Alzheimer's disease (AD) are not clear …

The inflammasome is a multiprotein complex involved in innate immunity that mediates the
inflammatory response leading to pyroptosis, which is a lytic, inflammatory form of cell death …