Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: a link with diabetes mellitus

I Valencia, J Lumpuy-Castillo, G Magalhaes… - Cardiovascular …, 2024 - Springer
Early since the onset of the COVID-19 pandemic, the medical and scientific community were
aware of extra respiratory actions of SARS-CoV-2 infection. Endothelitis, hypercoagulation …

Adaptive immunity and atherosclerosis: aging at its crossroads

RPM Snijckers, AC Foks - Frontiers in immunology, 2024 - frontiersin.org
Adaptive immunity plays a profound role in atherosclerosis pathogenesis by regulating
antigen-specific responses, inflammatory signaling and antibody production. However, as …

Three-year outcomes of post-acute sequelae of COVID-19

M Cai, Y Xie, EJ Topol, Z Al-Aly - Nature medicine, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes post-
acute sequelae of coronavirus disease 2019 (COVID-19)(PASC) in many organ systems …

The IRG1–itaconate axis protects from cholesterol-induced inflammation and atherosclerosis

Y Cyr, FK Bozal, JG Barcia Durán… - Proceedings of the …, 2024 - National Acad Sciences
Atherosclerosis is fueled by a failure to resolve lipid-driven inflammation within the
vasculature that drives plaque formation. Therapeutic approaches to reverse atherosclerotic …

Coronary inflammation on chest computed tomography and COVID-19 mortality

D Tuttolomondo, A Ticinesi, D Dey, C Martini… - European …, 2024 - Springer
Objectives The main factors associated with coronavirus disease-19 (COVID-19) mortality
are age, comorbidities, pattern of inflammatory response, and SARS-CoV-2 lineage involved …

Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity

J Al-Zadjali, A Al-Lawati, N Al Riyami, K Al Farsi… - Clinics, 2024 - SciELO Brasil
This controlled study investigated metabolic changes in non-vaccinated individuals with
Long-COVID-19, along with their connection to the severity of the disease. The study …

Identification of the needs of individuals affected by COVID-19

HB Stanley, V Pereda-Campos, M Mantel… - Communications …, 2024 - nature.com
Background The optimal management of COVID-19 symptoms and their sequelae remains
an important area of clinical research. Policy makers have little scientific data regarding the …

Post COVID-19 Reflections and Questions: How Prepared Are We for the Next Pandemic?

GJ Kontoghiorghes, A Kolnagou… - International Journal of …, 2024 - mdpi.com
While the end of the COVID-19 pandemic was announced earlier in 2023 by WHO, the
currently dominating COVID-19 virus variants, such as the omicron sub-lineages XBB. 1.5 …

Inflammatory response and defects on myelin integrity in the olfactory system of K18hACE2 mice infected with SARS-CoV-2

E Martin-Lopez, B Brennan, T Mao, N Spence… - eneuro, 2024 - eneuro.org
Viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), use
respiratory epithelial cells as an entry point for infection. Within the nasal cavity, the olfactory …

Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects

Y Zhang, S Chen, Y Tian, X Fu - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
SARS-CoV-2 is the causative virus of the devastating COVID-19 pandemic that results in an
unparalleled global health and economic crisis. Despite unprecedented scientific efforts and …