Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Over 10 years have passed since the deadly human coronavirus that causes severe acute
respiratory syndrome (SARS-CoV) emerged from the Guangdong Province of China …

Bortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed,
and newly diagnosed multiple myeloma (MM); however, dose-limiting toxicities and the …

Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene
products, reverse the modification of proteins by a single ubiquitin (-like) protein, and …

Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate
ubiquitination dynamics. Since their discovery, genetic and functional studies have …

The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin
moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in …

The COVID-19 pandemic has been disastrous to society and effective drugs are urgently
needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Converting lead compounds into drug candidates is a crucial step in drug development,
requiring early assessment of potency, selectivity, and off-target effects. We have utilized …