Streamlining spatial omics data analysis with Pysodb

S Lin, F Zhao, Z Wu, J Yao, Y Zhao, Z Yuan - Nature Protocols, 2024 - nature.com
Advances in spatial omics technologies have improved the understanding of cellular
organization in tissues, leading to the generation of complex and heterogeneous data and …

[HTML][HTML] A comprehensive overview of graph neural network-based approaches to clustering for spatial transcriptomics T. Liu et al. Overview of Spatial Transcriptomics …

T Liu, ZY Fang, Z Zhang, Y Yu, M Li, MZ Yin - Computational and Structural …, 2023 - Elsevier
Spatial transcriptomics technologies enable researchers to accurately quantify and localize
messenger ribonucleic acid (mRNA) transcripts at a high resolution while preserving their …

Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues

D Pham, X Tan, B Balderson, J Xu, LF Grice… - Nature …, 2023 - nature.com
Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …

Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST

Y Long, KS Ang, M Li, KLK Chong, R Sethi… - Nature …, 2023 - nature.com
Spatial transcriptomics technologies generate gene expression profiles with spatial context,
requiring spatially informed analysis tools for three key tasks, spatial clustering, multisample …

SODB facilitates comprehensive exploration of spatial omics data

Z Yuan, W Pan, X Zhao, F Zhao, Z Xu, X Li, Y Zhao… - Nature …, 2023 - nature.com
Spatial omics technologies generate wealthy but highly complex datasets. Here we present
Spatial Omics DataBase (SODB), a web-based platform providing both rich data resources …

Benchmarking spatial clustering methods with spatially resolved transcriptomics data

Z Yuan, F Zhao, S Lin, Y Zhao, J Yao, Y Cui… - Nature …, 2024 - nature.com
Spatial clustering, which shares an analogy with single-cell clustering, has expanded the
scope of tissue physiology studies from cell-centroid to structure-centroid with spatially …

Integrating spatial and single-cell transcriptomics data using deep generative models with SpatialScope

X Wan, J Xiao, SST Tam, M Cai, R Sugimura… - Nature …, 2023 - nature.com
The rapid emergence of spatial transcriptomics (ST) technologies is revolutionizing our
understanding of tissue spatial architecture and biology. Although current ST methods …

MENDER: fast and scalable tissue structure identification in spatial omics data

Z Yuan - Nature Communications, 2024 - nature.com
Tissue structure identification is a crucial task in spatial omics data analysis, for which
increasingly complex models, such as Graph Neural Networks and Bayesian networks, are …

Identifying spatial domains of spatially resolved transcriptomics via multi-view graph convolutional networks

X Shi, J Zhu, Y Long, C Liang - Briefings in Bioinformatics, 2023 - academic.oup.com
Motivation: Recent advances in spatially resolved transcriptomics (ST) technologies enable
the measurement of gene expression profiles while preserving cellular spatial context …

[HTML][HTML] A guidebook of spatial transcriptomic technologies, data resources and analysis approaches

L Yue, F Liu, J Hu, P Yang, Y Wang, J Dong… - Computational and …, 2023 - Elsevier
Advances in transcriptomic technologies have deepened our understanding of the cellular
gene expression programs of multicellular organisms and provided a theoretical basis for …