A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

AJ McGuinness, JA Davis, SL Dawson… - Molecular …, 2022 - nature.com
The emerging understanding of gut microbiota as 'metabolic machinery'influencing many
aspects of physiology has gained substantial attention in the field of psychiatry. This is …

Perturbations in gut microbiota composition in psychiatric disorders: a review and meta-analysis

VL Nikolova, MRB Smith, LJ Hall, AJ Cleare… - JAMA …, 2021 - jamanetwork.com
Importance Evidence of gut microbiota perturbations has accumulated for multiple
psychiatric disorders, with microbiota signatures proposed as potential biomarkers …

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

[HTML][HTML] The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

K Socała, U Doboszewska, A Szopa, A Serefko… - Pharmacological …, 2021 - Elsevier
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …

[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions

L Chang, Y Wei, K Hashimoto - Brain Research Bulletin, 2022 - Elsevier
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

Microbiota alterations in proline metabolism impact depression

J Mayneris-Perxachs, A Castells-Nobau… - Cell metabolism, 2022 - cell.com
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with
low treatment efficacy. However, the field is dominated by underpowered studies focusing …

Gut microbiome-wide association study of depressive symptoms

D Radjabzadeh, JA Bosch, AG Uitterlinden… - Nature …, 2022 - nature.com
Depression is one of the most poorly understood diseases due to its elusive pathogenesis.
There is an urgency to identify molecular and biological mechanisms underlying depression …

Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression

Z Li, J Lai, P Zhang, J Ding, J Jiang, C Liu… - Molecular …, 2022 - nature.com
The intricate processes of microbiota-gut-brain communication in modulating human
cognition and emotion, especially in the context of mood disorders, have remained elusive …

Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives

B Huang, SWH Chau, Y Liu, JWY Chan, J Wang… - Nature …, 2023 - nature.com
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's
disease (PD). Here we performed a cross-sectional study to profile gut microbiota across …

The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies

SR Alli, I Gorbovskaya, JCW Liu, NJ Kolla… - International journal of …, 2022 - mdpi.com
An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …