Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

The random recombination of immunoglobulin V (D) J gene segments produces unique IgM
antibodies that serve as the antigen receptor for each developing B cell. Hence, the newly …

High-throughput immune repertoire sequencing has emerged as a critical step in the
understanding of adaptive responses following infection or vaccination or in autoimmunity …

Objectives Immune and stromal cell communication is central in the pathogenesis of
rheumatoid arthritis (RA) and psoriatic arthritis (PsA), however, the nature of these …

The discovery that humans can produce potent broadly neutralizing antibodies (bNAbs) to
several different epitopes on the HIV-1 spike has reinvigorated efforts to develop an …

B cell clonal expansion is vital for adaptive immunity. High-throughput BCR sequencing
enables investigating this process but requires computational inference to identify clonal …

A hallmark of the adaptive immune system is the specificity of B cell and T cell responses.
Mechanistically, this feature relies on the fact that the two genes that encode B cell and T cell …

Given their essential role in adaptive immunity, antigen receptor loci have been the focus of
analysis for many years and are among a handful of the most well-studied genes in the …

Multiple methods have recently been developed to reconstruct full-length B-cell receptors
(BCRs) from single-cell RNA sequencing (scRNA-seq) data. This need emerged from the …

Kaposi sarcoma herpesvirus (KSHV/HHV-8) is a B cell tropic human pathogen, which is
present in vivo in monotypic immunoglobulin λ (Igλ) light chain but polyclonal B cells. In the …