Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Recent advances in the development and antimicrobial applications of metal–phenolic networks

Y Li, Y Miao, L Yang, Y Zhao, K Wu, Z Lu… - Advanced …, 2022 - Wiley Online Library
Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms,
medical devices, and related biomaterials are at high risk of microbial infection during use …

Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

[HTML][HTML] Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes

W Wang, X Jing, T Du, J Ren, X Liu, F Chen… - Free Radical Biology …, 2022 - Elsevier
Iron overload is a common phenomenon in the elderly population. Many clinical studies
have indicated an association between iron overload and the incidence and pathological …

Iron metabolism in aging and age-related diseases

Y Tian, Y Tian, Z Yuan, Y Zeng, S Wang, X Fan… - International journal of …, 2022 - mdpi.com
Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …

Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview

EE Alshial, MI Abdulghaney, AHS Wadan… - Life Sciences, 2023 - Elsevier
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Review of the role of ferroptosis in testicular function

X Yang, Y Chen, W Song, T Huang, Y Wang, Z Chen… - Nutrients, 2022 - mdpi.com
Iron is an important metal element involved in the regulation of male reproductive functions
and has dual effects on testicular tissue. A moderate iron content is necessary to maintain …

[HTML][HTML] The mechanisms of ferroptosis and its role in atherosclerosis

X Xu, XD Xu, MQ Ma, Y Liang, YB Cai, ZX Zhu… - Biomedicine & …, 2024 - Elsevier
Ferroptosis is a newly identified form of non-apoptotic programmed cell death, characterized
by the iron-dependent accumulation of lethal lipid reactive oxygen species (ROS) and …

Defective NCOA4-dependent ferroptosis in senescent fibroblasts retards diabetic wound healing

X Wei, M Liu, Z Zheng, S Yu, L Huang, J Ma… - Cell Death …, 2023 - nature.com
Cellular senescence describes a state of permanent proliferative arrest in cells. Studies
have demonstrated that diabetes promotes the pathological accumulation of senescent …

Mechanism of Iron Ion Homeostasis in Intestinal Immunity and Gut Microbiota Remodeling

H Bao, Y Wang, H Xiong, Y Xia, Z Cui, L Liu - International Journal of …, 2024 - mdpi.com
Iron is a vital trace element that plays an important role in humans and other organisms. It
plays an active role in the growth, development, and reproduction of bacteria, such as …