Antifungal drugs TDM: trends and update
B Kably, M Launay, A Derobertmasure… - Therapeutic Drug …, 2022 - journals.lww.com
Purpose: The increasing burden of invasive fungal infections results in growing challenges
to antifungal (AF) therapeutic drug monitoring (TDM). This review aims to provide an …
to antifungal (AF) therapeutic drug monitoring (TDM). This review aims to provide an …
[HTML][HTML] Clinical practice guideline for the therapeutic drug monitoring of voriconazole in non-Asian and Asian adult patients: consensus review by the Japanese …
Y Takesue, Y Hanai, K Oda, Y Hamada, T Ueda… - Clinical Therapeutics, 2022 - Elsevier
Purpose Voriconazole, an antifungal drug, is metabolized by a cytochrome P450 isozyme.
Increased adverse effects are observed in Asians because of the high rate of poor …
Increased adverse effects are observed in Asians because of the high rate of poor …
Physiologically based pharmacokinetic modeling of transdermal selegiline and its metabolites for the evaluation of disposition differences between healthy and …
A physiologically based pharmacokinetic (PBPK) model of selegiline (SEL), and its
metabolites, was developed in silico to evaluate the disposition differences between healthy …
metabolites, was developed in silico to evaluate the disposition differences between healthy …
[HTML][HTML] Physiologically based pharmacokinetic modeling of brivaracetam and its interactions with rifampin based on CYP2C19 phenotypes
H Yang, L Yang, X Zhong, X Jiang, L Zheng… - European Journal of …, 2022 - Elsevier
Abstract Brivaracetam (BRV), a third-generation antiepileptic drug (AED), is primarily
metabolized through amidase hydrolysis and CYP2C19-mediated hydroxylation in vivo. This …
metabolized through amidase hydrolysis and CYP2C19-mediated hydroxylation in vivo. This …
The alteration of drug metabolism enzymes and pharmacokinetic parameters in nonalcoholic fatty liver disease: current animal models and clinical practice
Y Zhu, L Chen, Y He, L Qin, D Tan, Z Bai… - Drug Metabolism …, 2023 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease. The whole
concept of NAFLD has now moved into metabolic dysfunction-associated fatty liver disease …
concept of NAFLD has now moved into metabolic dysfunction-associated fatty liver disease …
Physiologically‐based pharmacokinetic model predictions of inter‐ethnic differences in imatinib pharmacokinetics and dosing regimens
J Adiwidjaja, AS Gross, AV Boddy… - British Journal of …, 2022 - Wiley Online Library
Aims This study implements a physiologically‐based pharmacokinetic (PBPK) modelling
approach to investigate inter‐ethnic differences in imatinib pharmacokinetics and dosing …
approach to investigate inter‐ethnic differences in imatinib pharmacokinetics and dosing …
Cefiderocol in critically ill patients with multi-drug resistant pathogens: real-life data on pharmacokinetics and microbiological surveillance
Cefiderocol is a new siderophore-cephalosporin for the treatment of multi-drug resistant
Gram-negative pathogens. As a reserve agent, it will and should be used primarily in …
Gram-negative pathogens. As a reserve agent, it will and should be used primarily in …
Asia‐inclusive clinical Research and Development enabled by translational science and quantitative clinical pharmacology: toward a culture that challenges the status …
K Venkatakrishnan, N Gupta, PF Smith… - Clinical …, 2023 - Wiley Online Library
Access lag to innovative therapies in Asian populations continues to present a challenge to
global health. Recent progressive changes in the global regulatory landscape, including …
global health. Recent progressive changes in the global regulatory landscape, including …
PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes
CK Cho, E Ko, JY Mo, P Kang, CG Jang, SY Lee… - Archives of Pharmacal …, 2024 - Springer
Pantoprazole is used to treat gastroesophageal reflux disease (GERD), maintain healing of
erosive esophagitis (EE), and control symptoms related to Zollinger–Ellison syndrome …
erosive esophagitis (EE), and control symptoms related to Zollinger–Ellison syndrome …
CYP2C19 genotyping may provide a better treatment strategy when administering escitalopram in Chinese population
X Huang, C Li, C Li, Z Li, X Li, J Liao, T Rao… - Frontiers in …, 2021 - frontiersin.org
Depression disorder is one of the most serious mental illnesses in the world. Escitalopram is
the essential first-line medication for depression disorder. It is the substrate of hepatic …
the essential first-line medication for depression disorder. It is the substrate of hepatic …