Tear film inflammatory cytokine upregulation in contact lens discomfort

A Gad, AJ Vingrys, CY Wong, DC Jackson, LE Downie - The ocular surface, 2019 - Elsevier
Purpose To investigate the ocular inflammatory response, using clinical and immunological
techniques, in people experiencing contact lens (CL) discomfort. Methods This study …

Progressive loss of corneal nerve fibers and sensitivity in rats modeling obesity and type 2 diabetes is reversible with omega-3 fatty acid intervention: supporting …

L Coppey, E Davidson, H Shevalye… - … syndrome and obesity, 2020 - Taylor & Francis
Purpose To determine whether cornea nerve fiber density and/or corneal function are valid
markers for early detection and treatment of peripheral neuropathy in rats modeling …

Tear film evaluation and management in soft contact lens wear: a systematic approach

LE Downie, JP Craig - Clinical and Experimental Optometry, 2017 - Taylor & Francis
The human tear film is a highly ordered structure consisting of a thin layer of lipid on the
surface and a thicker aqueous‐mucin phase, which increases in mucin concentration toward …

[HTML][HTML] Effects of polyunsaturated fatty acids on nonspecific typical dry eye disease: a systematic review and meta-analysis of randomized clinical trials

SC Chi, HI Tuan, YN Kang - Nutrients, 2019 - mdpi.com
To investigate the effects of polyunsaturated fatty acids (PUFAs) in patients with dry eye
disease (DED), a multifactorial inflammatory disorder, we searched Cochrane Library …

[HTML][HTML] Association between systemic omega-3 polyunsaturated fatty acid levels, and corneal nerve structure and function

AC Britten-Jones, JP Craig, AJ Anderson, LE Downie - Eye, 2023 - nature.com
Background Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA)
and docosahexaenoic acid (DHA), have anti-inflammatory and neuroprotective properties …

Emerging therapies for dry eye disease

L Mason, S Jafri, I Dortonne… - Expert opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction Dry Eye Disease (DED) is defined as a multifactorial disease of the
ocular surface characterized by a loss of homeostasis of the tear film, and a vicious cycle of …

Omega‐3 fatty acids in the management of dry eye disease—An updated systematic review and meta‐analysis

C O'Byrne, M O'Keeffe - Acta Ophthalmologica, 2023 - Wiley Online Library
Purpose The purpose of this study was to examine the effectiveness of omega‐3 fatty acids
in comparison to a placebo in the management of dry eye disease. Methods A systematic …

Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease

H Jiao, LJ Hill, LE Downie… - Clinical and Experimental …, 2019 - Taylor & Francis
Optical coherence tomography (OCT) provides non‐invasive, high‐resolution in vivo
imaging of the ocular surface and anterior segment. Over the years, it has become an …

Risk factors influencing the occurrence and severity of symptomatic dry eye syndrome: a cross-sectional study

HR Choi, NH Kim, JM Lee, DP Choi, Y Seo… - Ophthalmic …, 2021 - Taylor & Francis
Propose: We aimed to investigate the prevalence and risk factors of dry eye syndrome (DES)
among a population-based cohort study. Methods: This cross-sectional study was conducted …

Randomized, masked, in vitro comparison of three commercially available tear film osmometers

G Rocha, E Gulliver, A Borovik, CC Chan - Clinical Ophthalmology, 2017 - Taylor & Francis
Purpose The purpose of this study was to compare the precision and accuracy of
commercially available tear film osmometers. Methods Contrived tear solution target values …