Atherosclerosis, diabetes mellitus, and cancer: common epidemiology, shared mechanisms, and future management

V Katsi, I Papakonstantinou, K Tsioufis - International Journal of …, 2023 - mdpi.com
The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

The emerging role of bile acids in white adipose tissue

A Schmid, T Karrasch, A Schäffler - Trends in Endocrinology & Metabolism, 2023 - cell.com
The effects of bile acids (BAs) on liver, enteroendocrine function, small intestine, and brown
adipose tissue have been described extensively. Outside the liver, BAs in the peripheral …

The metabolic syndrome, a human disease

M Alemany - International journal of molecular sciences, 2024 - mdpi.com
This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Benznidazole treatment decreases IL-6 levels in Trypanosoma cruzi-infected human adipocytes differentiated from adipose tissue-derived stem cells

LR Moreira, AC Silva, CN Costa Oliveira… - Memórias do Instituto …, 2023 - SciELO Brasil
BACKGROUND Trypanosoma cruzi, which causes Chagas disease (CD), is a versatile
haemoparasite that uses several strategies to evade the host's immune response, including …

Cytokine production by bovine adipose tissue stromal vascular fraction cells upon Neospora caninum stimulation

BM Oliveira, B Sidónio, A Correia, A Pinto… - Scientific Reports, 2024 - nature.com
In bovines few studies addressed the contribution of adipose tissue to the host immune
response to infection. Here we evaluated the in vitro response of bovine adipose tissue …

Transcriptomics analysis highlights potential ways in human pathogenesis in Leishmania braziliensis infected with the viral endosymbiont LRV1

KP Felipin, MV Paloschi, MDS Silva… - PLOS Neglected …, 2024 - journals.plos.org
The parasite Leishmania (Viannia) braziliensis is widely distributed in Brazil and is one of
the main species associated with human cases of different forms of tegumentary …

Interaction between peripheral blood mononuclear cells and Trypanosoma cruzi-infected adipocytes: implications for treatment failure and induction of …

LR Moreira, AC Silva, CN Costa-Oliveira… - Frontiers in …, 2024 - frontiersin.org
Background/Introduction Adipose tissue (AT) has been highlighted as a promising reservoir
of infection for viruses, bacteria and parasites. Among them is Trypanosoma cruzi, which …

The role of neck adipose tissue in lymph node metastasis of head and neck cancer

Y Pan, Y Xu, C Fan, X Miao, Y Shen, Q Wang… - Frontiers in …, 2024 - frontiersin.org
Previous studies indicated that adipose tissue significantly influences cancer invasion and
lymphatic metastasis. However, the impact of neck adipose tissue (NAT) on lymph node …

Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy

SS Jankauskas, F Varzideh, P Mone… - Military Medical …, 2024 - Springer
Background Diabetic cardiomyopathy is a disorder of the cardiac muscle that affects patients
with diabetes. The exact mechanisms underlying diabetic cardiomyopathy are mostly …

Effect of Obesity on the Pharmacokinetics and Pharmacodynamics of Anticancer Agents

WC Zamboni, R Charlab, GJ Burckart… - The Journal of …, 2023 - Wiley Online Library
An objective of the Precision Medicine Initiative, launched in 2015 by the US Food and Drug
Administration and National Institutes of Health, is to optimize and individualize dosing of …