Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …

The review presents modern views about the role of oxidative stress reactions in the
pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the …

Rheumatoid arthritis (RA) causes a huge medical burden due to its high morbidity and
disability rate. Emerging evidences demonstrate that RA has a tumor-like microenvironment …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …

Species of green macroalgae (Chlorophyta) of the genus Ulva are edible seaweeds with a
range of health promoting bioactive components. Ulva is high in dietary fibre which …

Numerous rheumatologic autoimmune diseases, among which rheumatoid arthritis, are
chronic inflammatory diseases capable of inducing multiple cumulative articular and extra …

Vitiligo is a common chronic acquired pigmentation disorder characterized by loss of
pigmentation. Among various hypotheses proposed for the pathogenesis of vitiligo, oxidative …

Mammalian cells possess a multifaceted antioxidant enzyme system, which includes
superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione …

The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …