Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal, not malignant, hematological
disease characterized by intravascular hemolysis, thrombophilia and bone marrow failure …

Hypertension is the primary cause of cardiovascular diseases (CVD) and is responsible for
nearly 9 million deaths worldwide annually. Increasing evidence indicates that in addition to …

Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …

Early and strong interferon type I (IFN-I) responses are usually associated with mild COVID-
19 disease, whereas persistent or unregulated proinflammatory cytokine responses are …

Vectored immunoprophylaxis was first developed as a means of establishing engineered
immunity to HIV using an adenoassociated viral vector expressing a broadly neutralizing …

Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disorder
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which had …

COVID-19 infection caused by SARS-CoV-2 is considered catastrophic because it affects
multiple organs, particularly those of the respiratory tract. Although the consequences of this …

Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of
vaccine-induced T and B cell responses and are specialized towards antibody-dependent …

The COVID-19 pandemic, which originated in Hubei, China, in December 2019, has had a
profound impact on global public health. With the elucidation of the SARS-CoV-2 virus …