Frailty, a consequence of the interaction of the aging process and certain chronic diseases,
compromises functional outcomes in the elderly and substantially increases their risk for …

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Sarcopenia is one of the main issues associated with the process of aging. Characterized by
muscle mass loss, it is triggered by several conditions, including sedentary habits and …

Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is
also related to chronic diseases such as metabolic dysfunction associated with diabetes and …

Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …

Obstructive sleep apnea (OSA) is an increasingly prevalent sleep disorder characterized by
upper airway obstruction during sleep, resulting in breathing pauses, intermittent hypoxia …

Abstract Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase,
COX) of the mitochondrial electron transport chain have been implicated in the …

Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …

Background The concept of mitochondrial dysfunction in ageing muscle is highly
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …