Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C

C Vollbracht, K Kraft - Frontiers in Pharmacology, 2022 - frontiersin.org
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

Does aging have an impact on vitamin C status and requirements? A scoping review of comparative studies of aging and institutionalisation

AC Carr, M Zawari - Nutrients, 2023 - mdpi.com
The global healthcare burden of an aging population continues to increase, with nearly a
quarter of the total global burden of disease attributable to people aged≥ 60 years. Older …

Vitamin C status in people with types 1 and 2 diabetes mellitus and varying degrees of renal dysfunction: relationship to body weight

AC Carr, E Spencer, H Heenan, H Lunt, M Vollebregt… - Antioxidants, 2022 - mdpi.com
Diabetes mellitus is a chronic metabolic disorder and is associated with depleted vitamin C
status. The underlying aetiologies and pathogeneses responsible for this association are …

Vitamin C deficiency in blood samples of COVID-19 patients

T Sinnberg, C Lichtensteiger, K Hill-Mündel… - Antioxidants, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is the most notable pandemic of the modern era. A
relationship between ascorbate (vitamin C) and COVID-19 severity is well known, whereas …

Effect of vitamin C on clinical outcomes of critically ill patients with COVID-19: an observational study and subsequent meta-analysis

E Gavrielatou, E Xourgia, NA Xixi, AG Mantelou… - Frontiers in …, 2022 - frontiersin.org
Background Whether vitamin C provides any benefit when administered in critically ill
patients, including those with coronavirus disease (COVID-19), is controversial. We …

Vitamin C improves gut Bifidobacteria in humans

S Hazan, S Dave, AJ Papoutsis, N Deshpande… - Future …, 2022 - Taylor & Francis
Aims: Numerous beneficial effects of vitamin C (ascorbic acid) supplementation have been
reported in the literature. However, data on its effects toward the gut microbiome are limited …

Multi-level immune support by vitamins C and D during the SARS-CoV-2 pandemic

AC Carr, AF Gombart - Nutrients, 2022 - mdpi.com
Vitamins C and D have well-known immune supportive roles, with deficiencies in both
vitamins predisposing to increased risk and severity of respiratory infections. Numerous …

COVID-19: Reducing the risk via diet and lifestyle

JL Campbell - Journal of Integrative Medicine, 2023 - Elsevier
This review shows that relatively simple changes to diet and lifestyle can significantly, and
rapidly, reduce the risks associated with coronavirus disease 2019 (COVID-19) in terms of …

Circulating protein carbonyls are specifically elevated in critically ill patients with pneumonia relative to other sources of sepsis

E Spencer, P Rosengrave, J Williman, G Shaw… - Free Radical Biology …, 2022 - Elsevier
Background Septic shock is a life-threatening dysregulated response to severe infection and
is associated with elevated oxidative stress. We aimed to assess protein carbonyls in …

Low vitamin C concentrations in patients with community-acquired pneumonia resolved with pragmatic administration of intravenous and oral vitamin C

AC Carr, E Vlasiuk, M Zawari, A Scott-Thomas… - Antioxidants, 2023 - mdpi.com
Community-acquired pneumonia (CAP) is characterized by elevated markers of
inflammation and oxidative stress and depleted circulating concentrations of the antioxidant …