The strategies to support the COVID-19 vaccination with evidence-based communication and tackling misinformation

P Rzymski, L Borkowski, M Drąg, R Flisiak, J Jemielity… - Vaccines, 2021 - mdpi.com
COVID-19 vaccinations are about to begin in various countries or are already ongoing. This
is an unprecedented operation that is also met with a loud response from anti-vaccine …

Oral antiviral treatments for COVID-19: opportunities and challenges

L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …

Drug repurposing for COVID-19: A review and a novel strategy to identify new targets and potential drug candidates

L Rodrigues, R Bento Cunha, T Vassilevskaia… - Molecules, 2022 - mdpi.com
In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the causative agent of coronavirus disease 2019 (COVID-19) was first identified in the …

Key considerations during the transition from the acute phase of the COVID-19 pandemic: a narrative review

P Rzymski, M Pokorska-Śpiewak, T Jackowska… - Vaccines, 2023 - mdpi.com
The COVID-19 pandemic has been met with an unprecedented response from the scientific
community, leading to the development, investigation, and authorization of vaccines and …

Discovery and evaluation of entry inhibitors for SARS-CoV-2 and its emerging variants

A Acharya, K Pandey, M Thurman, E Klug… - Journal of …, 2021 - Am Soc Microbiol
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
responsible for the coronavirus disease 19 (COVID-19) pandemic. Despite unprecedented …

Alkaloids in contemporary drug discovery to meet global disease needs

S Daley, GA Cordell - Molecules, 2021 - mdpi.com
An overview is presented of the well-established role of alkaloids in drug discovery, the
application of more sustainable chemicals, and biological approaches, and the …

COVID‐19 metabolism: Mechanisms and therapeutic targets

T Wang, Y Cao, H Zhang, Z Wang, CH Man… - MedComm, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral
signaling, immune response, and cell metabolism in human body. Viral genome and …

In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs

WKB Chan, KM Olson, JW Wotring, JZ Sexton… - Scientific Reports, 2022 - nature.com
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) requires treatments with rapid clinical translatability. Here we develop a multi-target …

Non-effectiveness of ivermectin on inpatients and outpatients with COVID-19; results of two randomized, double-blinded, placebo-controlled clinical trials

MS Rezai, F Ahangarkani, A Hill, L Ellis… - Frontiers in …, 2022 - frontiersin.org
Background Ivermectin which was widely considered as a potential treatment for COVID-19,
showed uncertain clinical benefit in many clinical trials. Performing large-scale clinical trials …

Bioengineering of novel non-replicating mRNA (NRM) and self-amplifying mRNA (SAM) vaccine candidates against SARS-CoV-2 using immunoinformatics approach

M Bhattacharya, AR Sharma, P Ghosh, P Patra… - Molecular …, 2022 - Springer
Presently, the world needs safe and effective vaccines to overcome the COVID-19
pandemic. Our work has focused on formulating two types of mRNA vaccines that differ in …