A validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 years

TW Kelsey, LQ Li, RT Mitchell, A Whelan… - PloS one, 2014 - journals.plos.org
The diagnosis of hypogonadism in human males includes identification of low serum
testosterone levels, and hence there is an underlying assumption that normal ranges of …

The hepatoprotective and hepatotoxic roles of sex and sex-related hormones

L Xu, Y Yuan, Z Che, X Tan, B Wu, C Wang… - Frontiers in …, 2022 - frontiersin.org
Most liver diseases, including acute liver injury, drug-induced liver injury, viral hepatitis,
metabolic liver diseases, and end-stage liver diseases, are strongly linked with hormonal …

Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice

T Poutahidis, A Springer, T Levkovich, P Qi, BJ Varian… - PLoS …, 2014 - journals.plos.org
The decline of circulating testosterone levels in aging men is associated with adverse health
effects. During studies of probiotic bacteria and obesity, we discovered that male mice …

Testosterone replacement therapy in patients with prostate cancer after radical prostatectomy

AW Pastuszak, AM Pearlman, WS Lai… - The Journal of …, 2013 - auajournals.org
Purpose: Testosterone replacement therapy in men with prostate cancer is controversial,
with concern that testosterone can stimulate cancer growth. We evaluated the safety and …

Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men

O Canguven, RA Talib, W El Ansari, DJ Yassin… - The Aging …, 2017 - Taylor & Francis
Background: The associations between serum vitamin D (VD), serum testosterone (TT) and
metabolic syndrome are complex and with limited published research, particularly on the …

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications

AK Lucas-Herald, R Alves-Lopes… - Clinical …, 2017 - portlandpress.com
The principle steroidal androgens are testosterone and its metabolite 5α-
dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α …

[HTML][HTML] Ginger and testosterone

SA Banihani - Biomolecules, 2018 - mdpi.com
Enhancing and protecting testosterone production is one target for many scientists because
of its crucial role as a primary sex hormone in males. Several in vivo trials have utilized …

[HTML][HTML] Revisiting the role of testosterone: Are we missing something?

V Tyagi, M Scordo, RS Yoon, FA Liporace… - Reviews in …, 2017 - ncbi.nlm.nih.gov
Testosterone is a pleiotropic hormone that plays an important role in the human body.
Classically, testosterone was thought to be predominantly involved in androgenesis and …

Hypogonadism in the aging male diagnosis, potential benefits, and risks of testosterone replacement therapy

PN Surampudi, C Wang… - International journal of …, 2012 - Wiley Online Library
Hypogonadism in older men is a syndrome characterized by low serum testosterone levels
and clinical symptoms often seen in hypogonadal men of younger age. These symptoms …

17β-Estradiol supplementation changes gut microbiota diversity in intact and colorectal cancer-induced ICR male mice

CH Song, N Kim, RH Nam, SI Choi, HN Lee, YJ Surh - Scientific reports, 2020 - nature.com
The composition of the gut microbiota is influenced by sex hormones and colorectal cancer
(CRC). Previously, we reported that 17β-estradiol (E2) inhibits azoxymethane/dextran …