An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat
chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of …

Psychedelics represent one of the most promising classes of experimental medicines for the
treatment of neuropsychiatric disorders due to their ability to promote neural plasticity and …

Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of
major depressive disorder. We investigated the effect of chronic social defeat stress, a …

The gut microbiota interacts with the host via neuroimmune, neuroendocrine and neural
pathways. These pathways are components of the brain-gut-microbiota axis and preclinical …

Major depressive disorder is a serious mental disorder that profoundly affects an individual's
quality of life. Although the aetiologies underlying this disorder remain unclear, an …

Naturally occurring food-derived active ingredients have received huge attention for their
chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) …

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Object Studies have suggested that depression was accompanied by oxidative stress
dysregulation, including abnormal total antioxidant capacity (TAC), antioxidants, free …

The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC …