Mesothelioma: Scientific clues for prevention, diagnosis, and therapy
M Carbone, PS Adusumilli… - CA: a cancer journal …, 2019 - Wiley Online Library
Mesothelioma affects mostly older individuals who have been occupationally exposed to
asbestos. The global mesothelioma incidence and mortality rates are unknown, because …
asbestos. The global mesothelioma incidence and mortality rates are unknown, because …
Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer
Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …
[HTML][HTML] Medical and surgical care of patients with mesothelioma and their relatives carrying germline BAP1 mutations
The most common malignancies that develop in carriers of BAP1 germline mutations include
diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and …
diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and …
[HTML][HTML] Emerging treatments for malignant pleural mesothelioma: where are we heading?
Malignant pleural mesothelioma (MPM) is an uncommon but aggressive and treatment
resistant neoplasm with low survival rates. In the last years we assisted to an exponential …
resistant neoplasm with low survival rates. In the last years we assisted to an exponential …
Phase 1 study of the immunotoxin LMB‐100 in patients with mesothelioma and other solid tumors expressing mesothelin
R Hassan, C Alewine, I Mian, A Spreafico, LL Siu… - Cancer, 2020 - Wiley Online Library
Background LMB‐100 is an antibody‐toxin conjugate with an antimesothelin Fab linked to a
24‐kilodalton portion of Pseudomonas exotoxin A with mutations that decrease …
24‐kilodalton portion of Pseudomonas exotoxin A with mutations that decrease …
[HTML][HTML] Targeting YB-1 via entinostat enhances cisplatin sensitivity of pleural mesothelioma in vitro and in vivo
K Schelch, D Emminger, B Zitta, TG Johnson, V Kopatz… - Cancer Letters, 2023 - Elsevier
Pleural mesothelioma (PM) is characterized by poor prognosis and limited therapeutic
options. Y-box-binding protein 1 (YB-1) was shown to drive growth and migration of PM …
options. Y-box-binding protein 1 (YB-1) was shown to drive growth and migration of PM …
BAP1 is a novel regulator of HIF-1α
BAP1 is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals
carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy …
carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy …
Exosomal transfer of miR-126 promotes the anti-tumour response in malignant mesothelioma: Role of miR-126 in cancer-stroma communication
MiR-126 has been shown to suppress malignant mesothelioma (MM) by targeting cancer-
related genes without inducing toxicity or histopathological changes. Exosomes provide the …
related genes without inducing toxicity or histopathological changes. Exosomes provide the …
Biomarker-guided targeted and immunotherapies in malignant pleural mesothelioma
H Yang, D Xu, RA Schmid… - Therapeutic advances in …, 2020 - journals.sagepub.com
Malignant pleural mesothelioma (MPM) is a lethal thoracic malignancy whose incidence is
still increasing worldwide. MPM is characterized by frequent inactivation of tumor …
still increasing worldwide. MPM is characterized by frequent inactivation of tumor …
[HTML][HTML] Asbestos-induced chronic inflammation in malignant pleural mesothelioma and related therapeutic approaches—a narrative review
AA Zolondick, G Gaudino, J Xue, HI Pass… - Precision cancer …, 2021 - ncbi.nlm.nih.gov
Objective: The aim of this review is addressing the mechanisms of asbestos carcinogenesis,
including chronic inflammation and autophagy-mediated cell survival, and propose potential …
including chronic inflammation and autophagy-mediated cell survival, and propose potential …