Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor
genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and …

DNA single-strand breaks (SSBs) are among the most common lesions arising in human
cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient …

Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …

Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis.
The availability of free tubulin subunits affects polymerization dynamics and microtubule …

Genome damage and transcription are intimately linked. Tens to hundreds of thousands of
DNA lesions arise in each cell each day, many of which can directly or indirectly impede …

UV irradiation induces" bulky" DNA photodimers such as (6-4)-photoproducts and
cyclobutane pyrimidine dimers that are removed by nucleotide excision repair, a complex …

Simple Summary A major theory of cancer development is that cancer originates from a
specialised type of tumour cell called the cancer stem cell (CSC). Although CSCs comprise …

Simple Summary DNA repair pathways play a crucial role in maintaining the stability of a
cell's genetic material. When these pathways are defective, it can lead to genomic instability …

Activation-induced cytidine deaminase (AID) is the essential enzyme for imprinting
immunological memory through class switch recombination (CSR) and somatic …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …