In the past decade, photoacoustic (PA) imaging has attracted a great deal of popularity as an
emergent diagnostic technology owing to its successful demonstration in both preclinical …

Early pregnancy is a complex and well-orchestrated differentiation process that involves all
the cellular elements of the fetal-maternal interface. Aberrant trophoblast-decidual …

Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly
from blastocysts, but their X chromosome state has remained unresolved. Here, we show …

X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of
gene expression, wherein the long non-coding RNA XIST spreads across the X …

There remains much that we do not understand about the earliest stages of human
development. On a gross level, there is evidence for apoptosis, but the nature of the affected …

Trophoblast (TB) comprises the outer cell layers of the mammalian placenta that make direct
contact with the maternal uterus and, in species with a highly invasive placenta, maternal …

Pbx genes encode transcription factors that belong to the TALE (three-amino-acid loop
extension) superclass of homeodomain proteins. We have witnessed a surge in information …

Dogs are an unparalleled natural model for investigating the genetics of health and disease,
particularly for complex diseases like cancer. Comprehensive genomic annotation of …

Is the human early embryo unique in lacking an inner cell-mass (ICM) and having parallel
development? We reanalyse single-cell transcriptomic data and stain human embryos in situ …

The common marmoset (Callithrix jacchus) is commonly used as a subject model animal in
experimental research. The species has several advantages compared with other laboratory …