[PDF][PDF] The role of hepatokines in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …
but it is also an important cause of insulin resistance and major non-communicable diseases …
Mini-Review for Journal of HepatologyTherapeutic opportunities for the treatment of NASH with genetically validated targets
D Lindén, S Romeo - Journal of Hepatology, 2023 - Elsevier
The identification of genetic variants associated with fatty liver disease (FLD) from genome
wide association studies (GWASs) started in 2008 when single nucleotide polymorphisms in …
wide association studies (GWASs) started in 2008 when single nucleotide polymorphisms in …
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …
effective treatments. We carried out a genome-wide association study (GWAS) meta …
[HTML][HTML] Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
[HTML][HTML] Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis
J Ghouse, G Sveinbjörnsson, M Vujkovic, AS Seidelin… - Nature Genetics, 2024 - nature.com
We report a multi-ancestry genome-wide association study on liver cirrhosis and its
associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase …
associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase …
[HTML][HTML] The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome
Background Recent studies found associations between non-alcoholic fatty liver disease
(NAFLD) and polycystic ovary syndrome (PCOS), but the causal nature of this association is …
(NAFLD) and polycystic ovary syndrome (PCOS), but the causal nature of this association is …
Genetic risk of fatty liver disease and mortality in the general population: A Mendelian randomization study
H Gellert‐Kristensen, A Tybjærg‐Hansen… - Liver …, 2023 - Wiley Online Library
Abstract Background & Aims Fatty liver disease has been associated with higher all‐cause
as well as liver‐related, ischemic heart disease (IHD)‐related and extrahepatic cancer …
as well as liver‐related, ischemic heart disease (IHD)‐related and extrahepatic cancer …
[HTML][HTML] Noninvasive assessment of hepatic decompensation
Noninvasive tests (NITs) are used in all aspects of liver disease management. Their most
prominent break-through since the millennium has been in advancing early detection of liver …
prominent break-through since the millennium has been in advancing early detection of liver …
[HTML][HTML] Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases
M Thiele, IF Villesen, L Niu, S Johansen, K Sulek… - Journal of …, 2024 - Elsevier
The rising prevalence of liver diseases related to obesity and excessive use of alcohol is
fuelling an increasing demand for accurate biomarkers aimed at community screening …
fuelling an increasing demand for accurate biomarkers aimed at community screening …